Article
The structure of Neisseria meningitidis lipid A determines outcome in experimental meningococcal disease.
Infection and immunity - 1 Jul 2010
Fransen Floris, Hamstra Hendrik Jan, Boog Claire J, van Putten Jos P, van den Dobbelsteen Germie P J M, van der Ley Peter
Abstract excerpt
Lipopolysaccharide (LPS), a major component of the meningococcal outer membrane, is sensed by the host through activation of Toll-like receptor 4 (TLR4). Recently, we demonstrated that a surprisingly large fraction of Neisseria meningitidis disease isolates are lipid A mutants, due to inactivating mutations in the lpxL1 gene. The lpxL1 mutants activate human TLR4 much less efficiently than wild-type bacteria,...
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