Article
6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor.
Experimental brain research - 1 Sept 1996
Bowenkamp K E, David D, Lapchak P L, Henry M A, Granholm A C, Hoffer B J, Mahalik T J
Abstract excerpt
Intraparenchymal injections of the neurotoxin 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle in rats destroys the dopaminergic neurons in the pars compacta of the substantia nigra. In other transmitter systems it has been found that axotomy or neurotoxin exposure produces an initial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.