Article
Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid.
Neuroscience - 1 May 1997
Alexi T, Venero J L, Hefti F
Abstract excerpt
Lesioning of the mammalian striatum with the excitotoxin quinolinic acid results in a pattern of neuropathology that resembles that of post mortem Huntington's disease brain. Certain neurotrophic factors can rescue degenerating cells in a variety of lesion types, including those produced by neuro...
Topics
- Animals
- Calcium-Binding Proteins
- Cell Count
- Choline O-Acetyltransferase
- Female
- Glutamate Decarboxylase
- Immunohistochemistry
- NADPH Dehydrogenase
- Neostriatum
- Nerve Degeneration
- Nerve Growth Factors
- Neurons
- Neuroprotective Agents
- Phenotype
- Quinolinic Acid
- Rats
- Rats, Wistar
- Transforming Growth Factor alpha