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Article

Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease.

Experimental neurology - 1 Feb 2004

Paul Gesine, Meissner Wassilios, Rein Susanne, Harnack Daniel, Winter Christine, Hosmann Kai, Morgenstern Rudolf, Kupsch Andreas

Abstract excerpt

Inhibition or ablation of the hyperactive subthalamic nucleus (STN) in Parkinson's disease (PD) does not only reverse motor deficits, silencing the glutamatergic output of the subthalamic nucleus, but has also been implicated to have neuroprotective effects on nigral neurons in animal models of Parkinson's disease. Ablation of the subthalamic nucleus has been shown to increase the number of...

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PMID: 14736508
DOI: 10.1016/s0014-4886(03)00363-7

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