Article
Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress.
Molecular & general genetics : MGG - 25 Sept 1996
Juhnke H, Krems B, Kötter P, Entian K D
Abstract excerpt
We have isolated several mutants of Saccharomyces cerevisiae that are sensitive to oxidative stress in a screen for elevated sensitivity to hydrogen peroxide. Two of the sixteen complementation groups obtained correspond to structural genes encoding enzymes of the pentose phosphate pathway. Allel...
Topics
- 3-Isopropylmalate Dehydrogenase
- Alcohol Oxidoreductases
- Amino Acid Sequence
- Carbohydrate Epimerases
- Cell Division
- Cloning, Molecular
- Drug Resistance, Microbial
- Fungal Proteins
- Gene Deletion
- Genes, Fungal
- Hydro-Lyases
- Hydrogen Peroxide
- Molecular Sequence Data
- Mutation
- Oxidants
- Oxidative Stress
- Pentose Phosphate Pathway
- Phosphogluconate Dehydrogenase