Article
Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae.
Applied microbiology and biotechnology - 1 Jul 2006
Gorsich S W, Dien B S, Nichols N N, Slininger P J, Liu Z L, Skory C D
Abstract excerpt
Engineering yeast to be more tolerant to fermentation inhibitors, furfural and 5-hydroxymethylfurfural (HMF), will lead to more efficient lignocellulose to ethanol bioconversion. To identify target genes involved in furfural tolerance, a Saccharomyces cerevisiae gene disruption library was screened for mutants with growth deficiencies in the presence of furfural. It was hypothesized that overexpression of these...
Topics
- Carbohydrate Epimerases
- Cellulose
- Furaldehyde
- Gene Expression Regulation, Fungal
- Glucosephosphate Dehydrogenase
- Heat-Shock Response
- Lignin
- Mutation
- Pentose Phosphate Pathway
- Saccharomyces cerevisiae