Article
The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant response.
Antioxidants & redox signaling - 15 Jul 2011
Krüger Antje, Grüning Nana-Maria, Wamelink Mirjam M C, Kerick Martin, Kirpy Alexander, Parkhomchuk Dimitri, Bluemlein Katharina, Schweiger Michal-Ruth, Soldatov Aleksey, Lehrach Hans, Jakobs Cornelis, Ralser Markus
Abstract excerpt
AIMS: A shift in primary carbon metabolism is the fastest response to oxidative stress. Induced within seconds, it precedes transcriptional regulation, and produces reducing equivalents in form of NADPH within the pentose phosphate pathway (PPP). RESULTS: Here, we provide evidence for a regulatory signaling function of this metabolic transition in yeast. Several PPP-deficiencies caused abnormal accumulation of...
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