Directed Evolution Reveals Unexpected Epistatic Interactions That Alter Metabolic Regulation and Enable Anaerobic Xylose Use by Saccharomyces cerevisiae.

doi:10.1371/journal.pgen.1006372

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Directed Evolution Reveals Unexpected Epistatic Interactions That Alter Metabolic Regulation and Enable Anaerobic Xylose Use by Saccharomyces cerevisiae.

PLoS genetics - 1 Oct 2016

Sato Trey K, Tremaine Mary, Parreiras Lucas S, Hebert Alexander S, Myers Kevin S, Higbee Alan J, Sardi Maria, McIlwain Sean J, Ong Irene M, Breuer Rebecca J, Avanasi Narasimhan Ragothaman, McGee Mick A, Dickinson Quinn, La Reau Alex, Xie Dan, Tian Mingyuan, Reed Jennifer L, Zhang Yaoping, Coon Joshua J, Hittinger Chris Todd, Gasch Audrey P, Landick Robert

Abstract excerpt

The inability of native Saccharomyces cerevisiae to convert xylose from plant biomass into biofuels remains a major challenge for the production of renewable bioenergy. Despite extensive knowledge of the regulatory networks controlling carbon metabolism in yeast, little is known about how to reprogram S. cerevisiae to ferment xylose at rates comparable to glucose. Here we combined genome sequencing, proteomic...

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PMID: 27741250
DOI: 10.1371/journal.pgen.1006372
PMCID: PMC5065143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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