Article
Variability of Human rDNA.
Cells - 20 Jan 2021
Smirnov Evgeny, Chmúrčiaková Nikola, Liška František, Bažantová Pavla, Cmarko Dušan
Abstract excerpt
In human cells, ribosomal DNA (rDNA) is arranged in ten clusters of multiple tandem repeats. Each repeat is usually described as consisting of two parts: the 13 kb long ribosomal part, containing three genes coding for 18S, 5.8S and 28S RNAs of the ribosomal particles, and the 30 kb long intergenic spacer (IGS). However, this standard scheme is, amazingly, often altered as a result of the peculiar instability of...
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