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Article

alpha/beta-Globin mRNA ratio determination by multiplex quantitative real-time reverse transcription-polymerase chain reaction as an indicator of globin gene function.

Clinical biochemistry - 1 Dec 2007

Chaisue Chulaporn, Kitcharoen Suttiphan, Wilairat Prapon, Jetsrisuparb Arunee, Fucharoen Goonnapa, Fucharoen Supan

Abstract excerpt

OBJECTIVES: Imbalance in alpha/beta-globin chains is an important determinant of thalassemia disease severity. This study examined the relationship between alpha/beta-globin mRNA ratio and disease severity in various thalassemia genotypes. DESIGN AND METHODS: alpha- and beta-globin mRNA contents of red blood cells of 75 alpha- and 32 beta-thalassemia subjects (5 with beta(0)-thalassemia/Hb E) and 14 normal...

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PMID: 17920577
DOI: 10.1016/j.clinbiochem.2007.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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