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Article

Von Hippel-Lindau gene alterations in sporadic benign and malignant pheochromocytomas.

International journal of cancer - 10 Jun 2003

Dannenberg Hilde, De Krijger Ronald R, van der Harst Erwin, Abbou Mustaffa, IJzendoorn Ynske, Komminoth Paul, Dinjens Winand N M

Abstract excerpt

The Von Hippel-Lindau (VHL) gene product has a wide spectrum of tissue-specific functions, and specific germline mutations are associated with clinical phenotypes in VHL disease. In particular, missense mutations are correlated with the susceptibility to pheochromocytomas. An association between VHL aberrations and prognosis has been suggested in renal clear cell carcinoma but has not been studied in...

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Source

Identifiers

PMID: 12673678
DOI: 10.1002/ijc.11060

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Von Hippel-Lindau gene alterations in sporadic benign and malignant pheochromocytomas.PMID 12673678Read ↗

Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.Semantic proximity Read ↗

Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas1Semantic proximity Read ↗

Mutations in the VHL tumor suppressor gene and associated lesions in families with von Hippel-Lindau disease from central Europe.Semantic proximity Read ↗

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype.Semantic proximity Read ↗

Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan.Semantic proximity Read ↗

Germline mutations in the von Hippel-Lindau disease (VHL) gene in Japanese VHL. Clinical Research Group for VHL in Japan.Semantic proximity Read ↗

Detection of von Hippel-Lindau disease gene mutations in paraffin-embedded sporadic renal cell carcinoma specimens.Semantic proximity Read ↗

Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations.Semantic proximity Read ↗

Genotype-phenotype correlation in von Hippel-Lindau syndrome.Semantic proximity Read ↗

Pathogenicity of VHL variants in families with non-syndromic von Hippel-Lindau phenotypes: An integrated evaluation of germline and somatic genomic results.Semantic proximity Read ↗

Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.Semantic proximity Read ↗

Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas.Semantic proximity Read ↗

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