Defective biliary excretion of epinephrine metabolites in mutant (TR-) rats: relation to the pathogenesis of black liver in the Dubin-Johnson syndrome and Corriedale sheep with an analogous excretory defect.

doi:10.1002/hep.1840150629

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Article

Defective biliary excretion of epinephrine metabolites in mutant (TR-) rats: relation to the pathogenesis of black liver in the Dubin-Johnson syndrome and Corriedale sheep with an analogous excretory defect.

Hepatology (Baltimore, Md.) - 1 Jun 1992

Kitamura T, Alroy J, Gatmaitan Z, Inoue M, Mikami T, Jansen P, Arias I M

Abstract excerpt

Dubin-Johnson patients, mutant Corriedale sheep and TR- and EHBR mutant rats have recessively inherited defective bile canalicular secretion of many nonbile acid organic anions. The human and ovine mutants have black livers and lysosomal pigment accumulation. The livers in TR- and EHBR mutant rats are not black, and sparse lysosomal pigment accumulation is seen. Previously, we postulated that the unidentified...

Topics

Animals
Anions
Bile
Epinephrine
Female
Food, Formulated
Humans
Jaundice, Chronic Idiopathic
Liver
Lysosomes
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metanephrine

Mutation

Phenylalanine

Pigmentation

Pigments, Biological

Rats

Rats, Mutant Strains

Source

Open in PubMed

Identifiers

PMID: 1592353
DOI: 10.1002/hep.1840150629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1592353-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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