Functional and phenotypic analyses of interleukin 2-activated tumor-infiltrating lymphocytes.

doi:10.1007/BF02173526

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Article

Functional and phenotypic analyses of interleukin 2-activated tumor-infiltrating lymphocytes.

Biotherapy (Dordrecht, Netherlands) - 1 Jan 1990

Yamaue H, Tanimura H, Tsunoda T, Iwahashi M, Tani M, Tamai M, Inoue M

Abstract excerpt

The tumor-infiltrating lymphocytes (TILs) were cultured with interleukin 2 (IL-2) to induce the activated killer cells possessing autologous tumor-killing activity, and analysed their cell surface phenotypes and assessed anti-tumor killing activity. Furthermore, the activated TILs were transferred into 7 patients adoptively resulting in complete remission in a patient with pancreatic cancer and partial remission...

Topics

Adult
Aged
Antigens, Differentiation, T-Lymphocyte
CD56 Antigen
Dose-Response Relationship, Drug
Female
Humans
Immunotherapy, Adoptive
Interleukin-2
Killer Cells, Lymphokine-Activated
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes, Tumor-Infiltrating

Male

Middle Aged

Neoplasms

Phenotype

T-Lymphocytes, Cytotoxic

Source

Open in PubMed

Identifiers

PMID: 1698423
DOI: 10.1007/BF02173526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1698423-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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