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Article

The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel.

Molecular pharmacology - 1 Jul 2001

Gruol D J, Bernd J, Phippard A E, Ojima I, Bernacki R J

Abstract excerpt

Murine thymoma cell lines expressing mutated forms of the mdr1b P-glycoprotein were isolated using a novel taxane-based P-glycoprotein inhibitor tRA-96023 (SB-RA-31012). The selection strategy required resistance to a combination of tRA-96023 and colchicine. Five mutations were identified (N350I, I862F, L865F, L868W, and A933T) that reduce the capacity of tRA-96023 to inhibit P-glycoprotein-dependent drug...

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Share to Antineoplastic Agents, Phytogenic
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Division

Share to Membrane Proteins

Share to Mice, Inbred BALB C

Share to Paclitaxel

Share to Taxoids

Share to Tumor Cells, Cultured

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Identifiers

PMID: 11408605
DOI: 10.1124/mol.60.1.104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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