Article
Effects of tubulin-inhibiting agents in human lung and breast cancer cell lines with different multidrug resistance phenotypes.
Oncology reports - 1 Jan 2000
van Ark-Otte J, Samelis G, Rubio G, Lopez Saez J B, Pinedo H M, Giaccone G
Abstract excerpt
Drug sensitivity was studied for the tubulin inhibitors taxol, taxotere, rhizoxin and for doxorubucin and cisplatin, in human lung and breast cancer cell lines, including drug-selected cell lines, overexpressing the membrane transporter P-glycoprotein (Pgp) or the multidrug resistance protein (MR...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Breast Neoplasms
- Cell Survival
- Cisplatin
- Docetaxel
- Doxorubicin
- Drug Resistance, Multiple
- Female
- Humans
- Lactones
- Lung Neoplasms
- Macrolides
- Microtubules
- Mitoxantrone
- Molecular Structure
- Paclitaxel
- Phenotype