Article
Immunohistochemical detection of truncated APC protein in sporadic human colorectal adenomas and adenocarcinomas.
Virchows Archiv : an international journal of pathology - 1 Sept 1996
Akehi S, Murao S, Ueda N, Okujima M, Magaribuchi T, Saheki S, Nishimukai H
Abstract excerpt
Mutations of the APC gene frequently occur in sporadic forms of colorectal adenomas and adenocarcinomas. Phenotypically, the vast majority of these mutations result in the truncation of the APC protein. To demonstrate the defective APC gene product in human colorectal tumors, rabbit region-specific antisera raised against the APC protein of amino acid sequences between 371 and 390 (SPI) and between 1821 and 1840...
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