Article
NRAMP1 gene polymorphisms in patients with rheumatoid arthritis.
Tissue antigens - 1 Jan 2000
Singal D P, Li J, Zhu Y, Zhang G
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease associated with HLA-DR genes that share amino acid sequence motif QKRAA/QRRAA from position 70 to 74 in the third hypervariable region of DR1 molecule. The contribution of HLA in RA is however about 37%, suggesting a role for other genes. One such candidate is the gene that encodes natural resistance-associated macrophage protein (NRAMP1), which...
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