Article
Familial amyotrophic lateral sclerosis.
Journal of neural transmission. Supplementum - 1 Jan 1997
Siddique T, Nijhawan D, Hentati A
Abstract excerpt
Amyotrophic lateral sclerosis is sporadic in ninety percent of cases and familial (FALS) in ten percent. Both forms of FALS whether transmitted as an autosomal dominant (DFALS) or as an autosomal recessive (RFALS) trait is genetically heterogeneous. The locus for one form of RFALS maps to chromos...
Topics
- Amyotrophic Lateral Sclerosis
- Animals
- Chromosome Mapping
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 21
- Exons
- Genes, Dominant
- Genes, Recessive
- Humans
- Mice
- Mice, Transgenic
- Motor Neurons
- Mutation
- Nerve Degeneration
- Point Mutation
- Sequence Deletion
- Superoxide Dismutase