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Article

Unraveling the multifaceted insights into amyotrophic lateral sclerosis: Genetic underpinnings, pathogenesis, and therapeutic horizons.

Mutation research. Reviews in mutation research - 1 Jan 2024

Sharma Ramaish, Khan Zuber, Mehan Sidharth, Das Gupta Ghanshyam, Narula Acharan S

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, primarily impairs upper and lower motor neurons, leading to debilitating motor dysfunction and eventually respiratory failure, widely known as Lou Gehrig's disease. ALS presents with diverse symptomatology, including dysarthria, dysphagia, muscle atrophy, and hyperreflexia. The prevalence of ALS varies globally, with incidence rates...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39491718
DOI: 10.1016/j.mrrev.2024.108518

Genes

C9ORF72
FUS
SOD1
TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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