Article
Selective recognition of M235T angiotensinogen variants and their determination in human plasma by monoclonal antibody-based immunoanalysis.
The Journal of clinical endocrinology and metabolism - 1 Oct 1996
Cohen P, Badouaille G, Gimenez-Roqueplo A P, Mani J C, Guyene T T, Jeunemaitre X, Menard J, Corvol P, Pau B, Simon D
Abstract excerpt
The common M235T mutation of human angiotensinogen has been shown to be associated with a 10-20% increase in plasma angiotensinOgen level and increased frequency of essential and pregnancy-induced hypertension. The detection of such a common factor in the plasma of individuals at risk could be a...
Topics
- Angiotensinogen
- Antibodies, Monoclonal
- Antibody Specificity
- Epitope Mapping
- Genotype
- Humans
- Immunoradiometric Assay
- Immunosorbent Techniques
- Mutation