Article
Detection and Quantification of Polymorphic MICA and MICB Molecules in Immunoassays: Initial Insights.
HLA - 1 Feb 2025
Stolbovaya A Yu, Pinevich A A, Gryazeva I V, Krutetskaya I Yu, Zharinov G M, Morozova M A, Kneev A Yu, Terekhina L A, Ishchuk S A, Shashkova O A, Vartanian N L, Samoylovich M P, Bezhenar V F, Sokolov D I, Selkov S A, Smirnov I V
Abstract excerpt
The MICA and MICB molecules, expressed on the cell membrane in response to cellular stress or cancer transformation, pose significant challenges for immunoassays. They exhibit high sequence and structural similarity, alongside considerable allelic polymorphism, with 291 and 53 known protein sequences, respectively. Some researchers treat MICA and MICB as a unified target because of their structural and functional...
Read the complete abstract on PubMedTopics
- Humans
- Histocompatibility Antigens Class I
- Female
- Antibodies, Monoclonal
- Polymorphism, Genetic