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Article

Normal Alpha-1-Antitrypsin Variants Display in Serum Allele-Specific Protein Levels.

Journal of proteome research - 7 Apr 2023

Jager Shelley, Cramer Dario A T, Heck Albert J R

Abstract excerpt

Alpha-1-antitrypsin (A1AT or SERPINA1) has been proposed as a putative biomarker distinguishing healthy from diseased donors throughout several proteomics studies. However, the SERPINA1 gene displays high variability of frequent occurring genotypes among the general population. These different genotypes may affect A1AT expression and serum protein concentrations, and this is often not known, ignored, and/or not...

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Identifiers

PMID: 36946534
DOI: 10.1021/acs.jproteome.2c00833
PMCID: PMC10088046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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