Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease.

doi:10.1016/s0006-291x(05)80834-4

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Article

Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease.

Biochemical and biophysical research communications - 15 Jul 1992

Petruzzella V, Chen X, Schon E A

Abstract excerpt

A specific mitochondrial DNA mutation at position 5460 in the ND2 gene of the human mitochondrial genome was recently reported to exist in 10 of 19 patients with Alzheimer's disease, implying an association between this mtDNA mutation and the occurrence of the disease. We have analyzed tissues from 15 patients with Alzheimer's disease for the presence of the ND2 mutation, and have not been able to confirm these...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Base Sequence
Brain
DNA
DNA, Mitochondrial
Female
Genome, Human
Humans
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 1352971
DOI: 10.1016/s0006-291x(05)80834-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1352971-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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