Article
Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair.
Genetics - 1 Aug 1996
Piruat J I, Aguilera A
Abstract excerpt
We have obtained genetic and molecular evidence that the hrs2-1 mutation, isolated as a suppressor of the hyperrecombination phenotype of hpr1 delta, is in the SRB2 gene, which encodes a component of the RNA polII holoenzyme. A newly constructed srb2 delta allele restores the wild-type levels of deletions in hpr1 delta cells, indicating that the lack of a functional SRB2 transcription factor suppresses...
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