Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair.

doi:10.1093/genetics/143.4.1533

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Article

Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair.

Genetics - 1 Aug 1996

Piruat J I, Aguilera A

Abstract excerpt

We have obtained genetic and molecular evidence that the hrs2-1 mutation, isolated as a suppressor of the hyperrecombination phenotype of hpr1 delta, is in the SRB2 gene, which encodes a component of the RNA polII holoenzyme. A newly constructed srb2 delta allele restores the wild-type levels of...

Topics

Alleles
DNA Repair
Drug Resistance, Microbial
Fungal Proteins
Genes, Fungal
Mediator Complex
Methyl Methanesulfonate
Mutagens
Mutation
Nuclear Proteins
Phenotype
Point Mutation
Recombination, Genetic
Repetitive Sequences, Nucleic Acid
Restriction Mapping
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Deletion

Source

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Identifiers

PMID: 8844143
DOI: 10.1093/genetics/143.4.1533
PMCID: PMC1207418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8844143-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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