Article
The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene.
Genetics - 1 Jan 1991
Rong L, Palladino F, Aguilera A, Klein H L
Abstract excerpt
The HPR5 gene has been defined by the mutation hpr5-1 that results in an increased rate of gene conversion. This mutation suppresses the UV sensitive phenotype of rad18 mutations in hpr5-1 rad18 double mutants by channeling the aborted repair events into a recombination repair pathway. The HPR5 gene has been cloned and is shown to be allelic to the SRS2/RADH gene, a putative DNA helicase. The HPR5 gene, which is...
Topics
- Alleles
- Base Sequence
- Cloning, Molecular
- DNA Helicases
- DNA Repair
- DNA, Fungal
- Epistasis, Genetic
- Gene Conversion
- Genes, Fungal
- Mitosis
- Mutation
- Recombination, Genetic