Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants.

Genetics - 1 Sept 1992

Palladino F, Klein H L

Abstract excerpt

The hyper-gene conversion srs2-101 mutation of the SRS2 DNA helicase gene of Saccharomyces cerevisiae has been reported to suppress the UV sensitivity of rad18 mutants. New alleles of SRS2 were recovered using this suppressor phenotype. The alleles have been characterized with respect to suppression of rad18 UV sensitivity, hyperrecombination, reduction of meiotic viability, and definition of the mutational...

Topics

Alleles
Amino Acid Sequence
DNA Helicases
DNA Repair
Diploidy
Gene Deletion
Genes, Fungal
Meiosis
Mitosis
Molecular Sequence Data
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Saccharomyces cerevisiae

Sequence Analysis, DNA

Suppression, Genetic

Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 1327956
DOI: 10.1093/genetics/132.1.23
PMCID: PMC1205121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1327956-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants.PMID 1327956Read ↗

Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein.Semantic proximity Read ↗

Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway.Semantic proximity Read ↗

The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway.Semantic proximity Read ↗

Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating-type heterozygosity.Semantic proximity Read ↗

Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.Semantic proximity Read ↗

Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free post-replication repair but not for damage-induced mutagenesis.Semantic proximity Read ↗

Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.Semantic proximity Read ↗

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase.Semantic proximity Read ↗

Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Semantic proximity Read ↗

Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover.Semantic proximity Read ↗

A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.