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Article

Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein.

The Journal of biological chemistry - 28 May 2004

Krejci Lumir, Macris Margaret, Li Ying, Van Komen Stephen, Villemain Jana, Ellenberger Thomas, Klein Hannah, Sung Patrick

Abstract excerpt

Mutants of the Saccharomyces cerevisiae SRS2 gene are hyperrecombinogenic and sensitive to genotoxic agents, and they exhibit a synthetic lethality with mutations that compromise DNA repair or other chromosomal processes. In addition, srs2 mutants fail to adapt or recover from DNA damage checkpoint-imposed G2/M arrest. These phenotypic consequences of ablating SRS2 function are effectively overcome by deleting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15047689
DOI: 10.1074/jbc.M402586200

Genes

RAD52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein.PMID 15047689Read ↗

Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.Semantic proximity Read ↗

Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants.Semantic proximity Read ↗

Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2.Semantic proximity Read ↗

Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Semantic proximity Read ↗

The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation.Semantic proximity Read ↗

A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability.Semantic proximity Read ↗

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase.Semantic proximity Read ↗

Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast.Semantic proximity Read ↗

Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2.Semantic proximity Read ↗

Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair.Semantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

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