Article
Systematic screening for mutations in the 5'-regulatory region of the human dopamine D1 receptor (DRD1) gene in patients with schizophrenia and bipolar affective disorder.
American journal of medical genetics - 26 Jul 1996
Cichon S, Nöthen M M, Stöber G, Schroers R, Albus M, Maier W, Rietschel M, Körner J, Weigelt B, Franzek E, Wildenauer D, Fimmers R, Propping P
Abstract excerpt
A possible dysregulation of dopaminergic neurotransmission has been implicated in a variety of neuropsychiatric diseases. In the present study we systematically searched for the presence of mutations in the 5'-flanking region of the dopamine D1 receptor (DRD1) gene. This region has previously been shown to contain a functional promoter [Minowa et al., 1992: Proc Natl Acad Sci 89:3045-3049; Minowa et al., 1993: J...
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