Article
Screening the dopamine D1 receptor gene in 131 schizophrenics and eight alcoholics: identification of polymorphisms but lack of functionally significant sequence changes.
American journal of medical genetics - 24 Apr 1995
Liu Q, Sobell J L, Heston L L, Sommer S S
Abstract excerpt
To determine whether mutations in the D1 dopamine receptor (D1 DR) gene are associated with schizophrenia, the coding sequence was examined in 106 Caucasian, 11 African-American, 8 Asian, and 6 Native American patients. Approximately 350 kb of genomic sequence was screened by dideoxy fingerprinti...
Topics
- Adolescent
- Adult
- Alcoholism
- Alleles
- Base Sequence
- Case-Control Studies
- DNA Fingerprinting
- DNA Primers
- Female
- Gene Amplification
- Humans
- Middle Aged
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Receptors, Dopamine D1
- Schizophrenia