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Article

Analysis of small nuclear RNAs in a precatalytic spliceosome.

Gene expression - 1 Jan 1996

Yean S L, Lin R J

Abstract excerpt

U1 small nuclear RNA plays an important role in early stages of intron recognition and spliceosome assembly. The 5' splice site of the premessenger RNA base-pairs with the 5' end of U1; however, that interaction appears to be replaced by U5 and U6 at later stages of the splicing process. It has not been established when this transition occurs nor what factors are required for the transition. The PRP2 gene of...

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Identifiers

PMID: 8836738
PMCID: PMC6138023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Analysis of small nuclear RNAs in a precatalytic spliceosome.PMID 8836738Read ↗

PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels.Semantic proximity Read ↗

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Semantic proximity Read ↗

A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.Semantic proximity Read ↗

Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae.Semantic proximity Read ↗

Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8.Semantic proximity Read ↗

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing.Semantic proximity Read ↗

The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.Semantic proximity Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.Semantic proximity Read ↗

RNA helicase dynamics in pre-mRNA splicing.Semantic proximity Read ↗

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