Article
Expression of Mts1, a metastasis-associated gene, increases motility but not invasion of a nonmetastatic mouse mammary adenocarcinoma cell line.
Oncogene - 16 Nov 1995
Ford H L, Salim M M, Chakravarty R, Aluiddin V, Zain S B
Abstract excerpt
The mts1 gene codes for a 101 amino acid protein belonging to the S100 subfamily of Ca(2+)-binding proteins. Mts1 is overexpressed in metastatic cancers as compared to their nonmetastatic counterparts, and although mts1 is known to be involved in the metastatic phenotype (Davies et al., 1993; Gri...
Topics
- Adenocarcinoma
- Animals
- Cell Movement
- Collagen
- Disease Progression
- Drug Combinations
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Laminin
- Mammary Neoplasms, Experimental
- Mice
- Mice, Inbred A
- Neoplasm Invasiveness
- Neoplasm Transplantation
- Phenotype
- Proteoglycans
- Transfection
- Tumor Cells, Cultured