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Article

Directed insertion of a selectable marker into a circular plasmid of Borrelia burgdorferi.

Journal of bacteriology - 1 Oct 1996

Rosa P, Samuels D S, Hogan D, Stevenson B, Casjens S, Tilly K

Abstract excerpt

Studies of the biology of Borrelia burgdorferi and the pathogenesis of Lyme disease are severely limited by the current lack of genetic tools. As an initial step toward facile genetic manipulation of this pathogenic spirochete, we have investigated gene inactivation by allelic exchange using a mutated borrelial gyrB gene that confers resistance to the antibiotic coumermycin A1 as a selectable marker. We have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 8830691
DOI: 10.1128/jb.178.20.5946-5953.1996
PMCID: PMC178451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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