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Article

Directed insertion of a selectable marker into a circular plasmid of Borrelia burgdorferi.

Journal of bacteriology - 1 Oct 1996

Rosa P, Samuels D S, Hogan D, Stevenson B, Casjens S, Tilly K

Abstract excerpt

Studies of the biology of Borrelia burgdorferi and the pathogenesis of Lyme disease are severely limited by the current lack of genetic tools. As an initial step toward facile genetic manipulation of this pathogenic spirochete, we have investigated gene inactivation by allelic exchange using a mu...

Topics

Alleles
Aminocoumarins
Anti-Bacterial Agents
Borrelia burgdorferi Group
Coumarins
DNA Gyrase
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Gene Transfer Techniques
Genetic Markers
Plasmids
Selection, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transformation, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 8830691
DOI: 10.1128/jb.178.20.5946-5953.1996
PMCID: PMC178451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8830691-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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