Article
The chemical cleavage of mismatch for the detection of mutations in long DNA fragments.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Tabone Tania, Sallmann Georgina, Cotton Richard G H
Abstract excerpt
Methods to rapidly scan large regions of DNA that are not dependent on highly specific melting temperatures or suitable only for large-scale discovery are important to reduce the amount of sequencing required for DNA samples that appear to contain a mutation. This protocol describes the chemical cleavage of mismatch method to assess if a region of DNA contains a mutation and accurately localize the position of...
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