Article
Sensitive and fast mutation detection by solid phase chemical cleavage.
Human mutation - 1 Jan 1996
Hansen L L, Justesen J, Kruse T A
Abstract excerpt
We have developed a solid phase chemical cleavage method (SpCCM) for screening large DNA fragments for mutations. All reactions can be carried out in microtiterwells from the first amplification of the patient (or test) DNA through the search for mutations. The reaction time is significantly reduced compared to the conventional chemical cleavage method (CCM), and even by using a uniformly labelled probe, the...
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