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Article

X-linked severe combined immunodeficiency: from molecular cause to gene therapy within seven years.

Molecular medicine today - 1 Oct 2000

Leonard W J

Abstract excerpt

X-linked severe combined immunodeficiency (XSCID) is the most common form of SCID. The discovery of the genetic defect in this disease, namely mutations in the gene encoding the common cytokine receptor gamma chain, gammac, was reported just over seven years ago. In the subsequent period, a tremendous amount of knowledge about the biology and function of this protein has been generated. Moreover, gammac-knockout...

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Identifiers

PMID: 11006530
DOI: 10.1016/s1357-4310(00)01782-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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