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Article

Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Mirochnitchenko O, Palnitkar U, Philbert M, Inouye M

Abstract excerpt

Exposure of humans and other mammals to hyperthermic conditions elicits many physiological responses to stress in various tissues leading to profound injuries, which eventually result in death. It has been suggested that hyperthermia may increase oxidative stress in tissues to form reactive oxygen species harmful to cellular functions. By using transgenic mice with human antioxidant genes, we demonstrate that the...

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Identifiers

PMID: 7667255
DOI: 10.1073/pnas.92.18.8120
PMCID: PMC41107

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Source receipt: pubmed, retrieved 7 Sept 2026.

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