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Article

Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Mirochnitchenko O, Palnitkar U, Philbert M, Inouye M

Abstract excerpt

Exposure of humans and other mammals to hyperthermic conditions elicits many physiological responses to stress in various tissues leading to profound injuries, which eventually result in death. It has been suggested that hyperthermia may increase oxidative stress in tissues to form reactive oxygen species harmful to cellular functions. By using transgenic mice with human antioxidant genes, we demonstrate that the...

Topics

Animals
Body Temperature Regulation
Cerebellum
Dinoprostone
Glutathione Peroxidase
HSP70 Heat-Shock Proteins
Hot Temperature
Humans
Hyperthermia, Induced
Hypothalamus
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Phenotype

RNA, Messenger

Recombinant Proteins

Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 7667255
DOI: 10.1073/pnas.92.18.8120
PMCID: PMC41107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7667255-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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