Article
Angiotensin converting enzyme gene polymorphism: potential silencer motif and impact on progression in IgA nephropathy.
Kidney international - 1 Feb 1996
Hunley T E, Julian B A, Phillips J A, Summar M L, Yoshida H, Horn R G, Brown N J, Fogo A, Ichikawa I, Kon V
Abstract excerpt
Since the renin angiotensin system (RAS) is established as an important factor in renal disease progression, we determined whether RAS alleles that have been linked to variability in outcome in several cardiovascular diseases also affect progression of IgA nephropathy. These genetic variants include: (1) angiotensin I converting enzyme deletion polymorphism in intron 16 (ACE I/D), reported to be associated with...
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