Article
A(-20)C polymorphism of the angiotensinogen gene and progression of IgA nephropathy.
Kidney international - 1 Sept 2002
Goto Shin, Narita Ichiei, Saito Noriko, Watanabe Yasuo, Yamazaki Hajime, Sakatsume Minoru, Shimada Hisaki, Nishi Shinichi, Ueno Mitsuhiro, Akazawa Kohei, Arakawa Masaaki, Gejyo Fumitake
Abstract excerpt
BACKGROUND: The M235T polymorphism of the angiotensinogen gene (AGT) is associated with an increased risk of primary hypertension, which may then lead to progressive renal disease. Recent studies showed that nucleotide substitution in the 5' upstream core promoter region of AGT affects the basal transcription rate of the gene. METHODS: To evaluate the role of AGT polymorphisms in the progression of IgA...
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