Article
The renin--angiotensin system gene polymorphisms and clinicopathological correlations in IgA nephropathy.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet - 1 Jul 1999
Ong-Ajyooth S, Ong-Ajyooth L, Limmongkon A, Tiensingh A, Parichatikanon P, Nilwarangkur S
Abstract excerpt
Genetic variability in the renin-angiotensin system (RAS) may modify renal responses to injury and disease progression. We examined whether RAS alleles affect severity of IgA nephropathy. These genetic variants include angiotensin I converting enzyme deletion polymorphism in intron 16 (ACE I/D), a point mutation in the angiotensinogen (AGT) gene resulting in a methionine to threonine substitution at residue 235...
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