Sequential mutations of gyrA in Escherichia coli associated with quinolone therapy.

doi:10.1093/jac/36.6.1055

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Article

Sequential mutations of gyrA in Escherichia coli associated with quinolone therapy.

The Journal of antimicrobial chemotherapy - 1 Dec 1995

Truong Q C, Ouabdesselam S, Hooper D C, Moreau N J, Soussy C J

Abstract excerpt

A clinical isolate of Escherichia coli HM73 (MIC norfloxacin 2 mg/L) was isolated during norfloxacin therapy from an urinary tract infection in a patient who had been previously treated with pipemidic acid and infected by E. coli HM72 (norfloxacin 0.25), known to harbour a substitution Ser 83-->L...

Topics

Aged
Aged, 80 and over
Anti-Infective Agents
Ciprofloxacin
Codon
DNA Gyrase
DNA Topoisomerases, Type II
Escherichia coli
Humans
Mutation
Norfloxacin
Plasmids
Urinary Tract Infections

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