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Article

Variant and Masked Translocations in Acute Promyelocytic Leukemia

1 Jan 1996

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by a unique hemorrhagic syndrome, disseminated intravascular coagulation, and the association with the specific (15;17 chi q22-23:q12-21) translocation, which disrupts the retinoic acid receptor alpha (RARA) and the promyelocytic leukemia (PML) genes. The t(15;17) leads to the formation of two reciprocal fusion genes, PML/RARA on chromosome 15 and RARA/PML on...

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Identifiers

PMID: 8819070
DOI: 10.3109/10428199609051752

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