Detection of PML-RAR alpha fusion transcript in Ph positive leukemia with acute promyelocytic phenotype lacking the t(15;17) cytogenetic abnormality.

doi:10.1016/0165-4608(94)00147-4

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Article

Detection of PML-RAR alpha fusion transcript in Ph positive leukemia with acute promyelocytic phenotype lacking the t(15;17) cytogenetic abnormality.

Cancer genetics and cytogenetics - 1 Apr 1995

Emilia G, Marasca R, Longo G, Ferrari M G, Notohamiprodjo M, Temperani P, Sacchi S, Torelli G

Abstract excerpt

A 39-year-old woman was diagnosed with acute promyelocytic leukemia (APL) with disseminated intravascular coagulation syndrome. The hematologic examination showed a morphologic, cytochemical, and immunophenotypic picture typical of an APL, with a marked leukocytosis and a mixed population of hypergranular and microgranular promyelocytes. The cytogenetic analysis showed a 46,XX,t(9;22) karyotype, without any...

Topics

Adult
Base Sequence
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
DNA Primers
Female
Humans
In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Karyotyping

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Leukemia, Promyelocytic, Acute

Molecular Sequence Data

Phenotype

RNA, Messenger

Receptors, Retinoic Acid

Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 7736444
DOI: 10.1016/0165-4608(94)00147-4

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7736444-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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