Article
RARA and PML gene rearrangements in acute promyelocytic leukemia with complex translocations and atypical features.
Genes, chromosomes & cancer - 1 Jan 1994
McKinney C D, Golden W L, Gemma N W, Swerdlow S H, Williams M E
Abstract excerpt
The translocation t(15;17) associated with acute promyelocytic leukemia (APL) results in fusion of the retinoic acid receptor alpha (RARA) gene on chromosome 17 with the putative transcription factor gene, PML, on chromosome 15. We report three cases of APL with complex cytogenetic translocations and five cases with atypical phenotypic features with rearrangements within or adjacent to the second intron of the...
Topics
- Adolescent
- Adult
- Aged
- Chromosome Banding
- Chromosome Mapping
- Chromosomes, Human, Pair 15
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 3
- Female
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor