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Article

Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice

1 Aug 2002

Abstract excerpt

IGF binding protein-1 (IGFBP-1) is a secretory product of decidualized endometrium and a major constituent of amniotic fluid. It is thought to modulate the actions of the IGFs on trophoblast cells and is therefore potentially important in regulating placental development and fetal growth. To investigate this hypothesis, we have studied the effects of decidual IGFBP-1 excess on fetoplacental growth in transgenic...

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PMID: 12163461
DOI: 10.1172/jci10077

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