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Article

HIV-1 syncytium-inducing phenotype, virus burden, codon 215 reverse transcriptase mutation and CD4 cell decline in zidovudine-treated patients.

Journal of acquired immune deficiency syndromes - 1 Aug 1994

Kozal M J, Shafer R W, Winters M A, Katzenstein D A, Aguiniga E, Halpern J, Merigan T C

Abstract excerpt

The variable rate of disease progression in HIV-1-infected patients treated with zidovudine may be related to certain viral characteristics, such as, antiviral drug resistance, virus burden, and viral syncytium-inducing (SI) capacity. Thirty-two HIV-1-infected patients treated with zidovudine (mean of 34 months) were studied to determine the relationship of SI phenotype and the codon 215 pol gene mutation (a...

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PMID: 7517448

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