Article
HIV-1 syncytium-inducing phenotype, virus burden, codon 215 reverse transcriptase mutation and CD4 cell decline in zidovudine-treated patients.
Journal of acquired immune deficiency syndromes - 1 Aug 1994
Kozal M J, Shafer R W, Winters M A, Katzenstein D A, Aguiniga E, Halpern J, Merigan T C
Abstract excerpt
The variable rate of disease progression in HIV-1-infected patients treated with zidovudine may be related to certain viral characteristics, such as, antiviral drug resistance, virus burden, and viral syncytium-inducing (SI) capacity. Thirty-two HIV-1-infected patients treated with zidovudine (me...
Topics
- CD4-Positive T-Lymphocytes
- Codon
- DNA, Viral
- Drug Resistance, Microbial
- Genotype
- Giant Cells
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Leukocyte Count
- Leukocytes, Mononuclear
- Mutation
- Phenotype
- Proviruses
- RNA, Viral
- RNA-Directed DNA Polymerase
- Regression Analysis