Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2).

Journal of autoimmunity - 1 Jun 1996

Imagawa A, Hanafusa T, Itoh N, Miyagawa J, Nakajima H, Namba M, Kuwajima M, Tamura S, Kawata S, Matsuzawa Y, Harlan D M

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) results mainly from T cell mediated pancreatic beta cell destruction. To fully activate antigen specific T cells, current evidence suggests that two signals are required. One signal is delivered via the antigen specific T cell receptor (TCR) when engaged...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-1 Antigen
Share to CD3 Complex
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Islets of Langerhans

Share to Phenotype

Share to T-Lymphocytes

Source

Identifiers

PMID: 8816976
DOI: 10.1006/jaut.1996.0053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8816976-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2).PMID 8816976Read ↗

Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse.Semantic proximity Read ↗

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8 <sup>+</sup> T cells in autoimmune diabetesSemantic proximity Read ↗

beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct.Semantic proximity Read ↗

A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.Semantic proximity Read ↗

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 DiabetesSemantic proximity Read ↗

Expression of B7 and CD28 family genes in newly diagnosed type 1 diabetes.Semantic proximity Read ↗

Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.Semantic proximity Read ↗

Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells.Semantic proximity Read ↗

Dysregulated B7-1 and B7-2 expression on nonobese diabetic mouse B cells is associated with increased T cell costimulation and the development of insulitis.Semantic proximity Read ↗

I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice.Semantic proximity Read ↗

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.Semantic proximity Read ↗

Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.