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YY1 and NF1 Both Activate the Human p53 Promoter by Alternatively Binding to a Composite Element, and YY1 and E1A Cooperate To Amplify p53 Promoter Activity

1 Oct 1996

Abstract excerpt

A novel transcription factor binding element in the human p53 gene promoter has been characterized. It lies about 100 bp upstream of the major reported start site for human p53 gene transcription. On the basis of DNase I footprinting studies, electromobility shift assay patterns, sequence specificity of binding, the binding pattern of purified transcription factors, effects of specific antibodies, and methylation...

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Identifiers

PMID: 8816507
DOI: 10.1128/mcb.16.10.5933

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Related research

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YY1 and NF1 Both Activate the Human p53 Promoter by Alternatively Binding to a Composite Element, and YY1 and E1A Cooperate To Amplify p53 Promoter ActivityPMID 8816507Read ↗

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The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in nonpermissive cellsSemantic proximity Read ↗

Yin Yang 1 Negatively Regulates the Differentiation-Specific E1 Promoter of Human Papillomavirus Type 6Semantic proximity Read ↗

Functional analysis of the promoter region of the human phosphotyrosine phosphatase activator gene: Yin Yang 1 is essential for core promoter activity.Semantic proximity Read ↗

Differential regulation of human <i>YY1</i> and <i>caspase 7</i> promoters by prohibitin through E2F1 and p53 binding sitesSemantic proximity Read ↗

Cloning and characterization of murine p53 upstream sequences reveals additional positive transcriptional regulatory elements.Semantic proximity Read ↗

Yin-Yang 1 Activates Interleukin-4 Gene Expression in T CellsSemantic proximity Read ↗

YY1 is a positive regulator of transcription of the Col1a1 gene.Semantic proximity Read ↗

Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine beta-hydroxylase gene.Semantic proximity Read ↗

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