Article
Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.
Molecular and cellular biology - 1 May 2005
Imbriano Carol, Gurtner Aymone, Cocchiarella Fabienne, Di Agostino Silvia, Basile Valentina, Gostissa Monica, Dobbelstein Matthias, Del Sal Giannino, Piaggio Giulia, Mantovani Roberto
Abstract excerpt
In response to DNA damage, p53 activates G(1)/S blocking and apoptotic genes through sequence-specific binding. p53 also represses genes with no target site, such as those for Cdc2 and cyclin B, key regulators of the G(2)/M transition. Like most G(2)/M promoters, they rely on multiple CCAAT boxes activated by NF-Y, whose binding to DNA is temporally regulated during the cell cycle. NF-Y associates with p53 in...
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