Article
Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation.
Molecular and cellular biology - 1 Oct 1996
Miller M E, Cairns B R, Levinson R S, Yamamoto K R, Engel D A, Smith M M
Abstract excerpt
Expression of the adenovirus E1A243 oncoprotein in Saccharomyces cerevisiae produces a slow-growth phenotype with accumulation of cells in the G1 phase of the cell cycle. This effect is due to the N-terminal and CR1 domains of E1A243, which in rodent cells are involved in triggering cellular transformation and also in binding to the cellular transcriptional coactivator p300. A genetic screen was undertaken to...
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