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Article

Double mutant P96S/S120G of Nm23-H1 abrogates its NDPK activity and motility-suppressive ability.

Biochemical and biophysical research communications - 4 May 2007

Zhou Qinghua, Yang Xueqin, Zhu Daxing, Ma Li, Zhu Wen, Sun Zhilin, Yang Qin

Abstract excerpt

The Nm23-H1 gene is a metastasis suppressor gene. However, its biochemical mechanism of suppressing the metastatic potential of cancer cells is still unknown. The previous hypothesis that a histidine protein kinase activity may contributes to the motility-suppressive effect of Nm23-H1 could not explain why the H118F mutant, a kinase-deficient mutant, still had motility-suppressive ability. We conducted a study on...

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PMID: 17335772
DOI: 10.1016/j.bbrc.2007.02.066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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